phpLedMailer looks pretty good. Thanks Scott!
I have requested an install script for it here (FS#3877):
http://www.virtualmin.com/index.php?option=com_flyspray&Itemid=82&show_task=3877To answer the OP question, phpList does need to be installed once per domain, but it supports multiple mailing lists in that domain. On the other hand, phpLedMailer needs to be installed once per LIST, even in the same domain.
phpList is a very good and fairly well-supported script, but as Scott stated, it is a bit complex to setup and manage, especially for new users. I find that I wind up answering so many questions on it that it is often easier for me to just send out the mailing on my customer's behalf. But phpLedMailer looks much easier for this purpose that most users should be able to figure it out on their own, especially if they only have a single mailing list (which is probably the most common scenario).
Alan