The biggest spam problem occurring at the moment (for about the past 2 months) is NDRs (Non-Delivery Receipts) -- 554 (service unavailable) or 550 (user unknown) "bounce" errors. These are legitimate responses from mailservers which have been hit using reply-to addresses harvested from your web users.
Although this sort of attack has been used sporadically in the past, it now seems to be commonplace. We have 2 or 3 users per day complaining about it. It appears to actually be a tactic to get users to actually open and investigate, and click the links inside the NDR's if they copy the message text back to the reply-to recipient.
Load on our mailservers is higher than it has been since we started using Postini to filter the majority of our mail and mailservers.
More info:
http://www.chattanooga.net/20080407112/faqs/web-hosting/email-cloaking.html(yes, I wrote that FAQ so I could easily reply to the hundreds of customers who are complaining about this very issue).